Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis.

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Article

Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis.

Osteoarthritis and cartilage - 1 Jan 2001

So C L, Kaluarachchi K, Tam P P, Cheah K S

Abstract excerpt

OBJECTIVE: Chondrocytes in the growth plate at different stages of differentiation synthesize characteristic extracellular matrix (ECM) components. Mutations in some ECM genes result in chondrodysplasia in humans and mice. We aimed to evaluate the impact of loss- and gain-of-function mutations of ECM genes on matrix structure, gene expression and formation of the growth plate. DESIGN: We review information on the...

Topics

Aggrecans
Animals
Cartilage, Articular
Chondrocytes
Collagen Type I
Collagen Type II
Collagen Type IX
Collagen Type X
Extracellular Matrix
Extracellular Matrix Proteins
Gene Expression
Growth Plate
In Situ Hybridization
Lectins, C-Type
Mice
Mice, Transgenic
Mutation
Proteoglycans

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Identifiers

PMID: 11680681

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