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Article

Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis.

Osteoarthritis and cartilage - 1 Jan 2001

So C L, Kaluarachchi K, Tam P P, Cheah K S

Abstract excerpt

OBJECTIVE: Chondrocytes in the growth plate at different stages of differentiation synthesize characteristic extracellular matrix (ECM) components. Mutations in some ECM genes result in chondrodysplasia in humans and mice. We aimed to evaluate the impact of loss- and gain-of-function mutations of ECM genes on matrix structure, gene expression and formation of the growth plate. DESIGN: We review information on the...

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PMID: 11680681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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