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Article

Reagents that block neuronal death from Huntington's disease also curb oxidative stress.

Neuroreport - 4 Jan 2012

Valencia Antonio, Sapp Ellen, Reeves Patrick B, Alexander Jonathan, Masso Nicholas, Li Xueyi, Kegel Kimberly B, DiFiglia Marian

Abstract excerpt

Patients with Huntington's disease suffer severe neuronal loss and signs of oxidative damage in the brain. Previously we found that primary neurons from embryonic cortex of mice bearing the Huntington's disease mutation (140 glutamines inserted into exon 1 of huntingtin) showed higher levels of reactive oxygen species before cell death. Here, we treated mutant neurons with known neuroprotective agents and...

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Identifiers

PMID: 22045254
DOI: 10.1097/WNR.0b013e32834d92e6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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