Article
Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype.
Pharmacology, biochemistry, and behavior - 1 Nov 2005
Tadros Mariane G, Khalifa Amani E, Abdel-Naim Ashraf B, Arafa Hossam M M
Abstract excerpt
An experimental animal model of Huntington's disease (HD) phenotype was induced using the mycotoxin 3-nitropropionic acid (3-NP) and was well characterized behaviorally, neurochemically, morphometrically and histologically. Administration of 3-NP caused a reduction in prepulse inhibition (PPI) of acoustic startle response, locomotor hyper- and/or hypoactivity, bilateral striatal lesions, brain oxidative stress,...
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