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Article

Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa.

Antiviral therapy - 1 Jan 2013

Hoffmann Christopher J, Ledwaba Johanna, Li Jin-Fen, Johnston Victoria, Hunt Gillian, Fielding Katherine L, Chaisson Richard E, Churchyard Gavin J, Grant Alison D, Johnson Jeffrey A, Charalambous Salome, Morris Lynn

Abstract excerpt

BACKGROUND: Tenofovir disoproxil fumarate (TDF) is increasingly available for patients infected with subtype C HIV-1. This subtype is reported to develop the principal TDF resistance mutation in the HIV reverse transcriptase, K65R, with greater propensity than other subtypes. We sought to describe K65R development during TDF use in a cohort of patients infected with subtype C HIV. METHODS: Using a prospectively...

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Identifiers

PMID: 23751421
DOI: 10.3851/IMP2652
PMCID: PMC4046272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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