Article
Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing.
AIDS (London, England) - 24 Apr 2016
Casadellà Maria, Noguera-Julian Marc, Sunpath Henry, Gordon Michelle, Rodriguez Cristina, Parera Mariona, Kuritzkes Daniel R, Marconi Vincent C, Paredes Roger
Abstract excerpt
In a South African cohort of participants living with HIV developing virological failure on first-line tenofovir disoproxyl fumarate (TDF)-based regimens, at least 70% of participants demonstrated TDF resistance according to combined Sanger and MiSeq genotyping. Sanger sequencing missed the K65R mutation in 30% of samples. Unless HIV genotyping is available to closely monitor epidemiological HIV resistance to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.