K65R development among subtype C HIV-1-infected patients in tenofovir DF clinical trials

Abstract excerpt

A recent study demonstrated a greater propensity for HIV-1 subtype C to develop a K65R mutation under in-vitro selection with tenofovir compared with subtype B or other non-B subtypes [1]. The mechanistic basis for this in-vitro observation was not clear because the single nucleotide change is identical for the K65R substitution in either subtype B or subtype C. For subtype B, a switch from AAA to AGA occurs. For...

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