Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase.

doi:10.1093/hmg/ddl034

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Article

Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase.

Human molecular genetics - 1 Apr 2006

Huang Ting-Ting, Naeemuddin Mohammed, Elchuri Sailaja, Yamaguchi Mutsuo, Kozy Heather M, Carlson Elaine J, Epstein Charles J

Abstract excerpt

Sod2-/- mice, which are deficient in the mitochondrial form of superoxide dismutase (MnSOD), have a short survival time that is strongly affected by genetic background. This suggests the existence of genetic modifiers that are capable of modulating the degree of mitochondrial oxidative damage caused by the MnSOD deficiency, thereby altering longevity. To identify these modifier(s), we generated recombinant...

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PMID: 16497723
DOI: 10.1093/hmg/ddl034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.