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Article

Mitochondrial NADPH, transhydrogenase and disease.

Biochimica et biophysica acta - 1 Jan 2000

Rydström Jan

Abstract excerpt

Ever since its discovery in 1953 by N. O. Kaplan and coworkers, the physiological role of the proton-translocating transhydrogenase has generally been assumed to be that of generating mitochondrial NADPH. Mitochondrial NADPH can be used in a number of important reactions/processes, e.g., biosynthesis, maintenance of GSH, apoptosis, aging etc. This assumed role has found some support in bacteria but not in higher...

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PMID: 16730324
DOI: 10.1016/j.bbabio.2006.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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