Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Dec 2020

Kunath Anne, Heiker John T, Kern Matthias, Kosacka Joanna, Flehmig Gesine, Stumvoll Michael, Kovacs Peter, Blüher Matthias, Klöting Nora

Abstract excerpt

The C57BL/6J (B6J) mouse strain has been widely used as a control strain for the study of metabolic diseases and diet induced obesity (DIO). B6J mice carry a spontaneous deletion mutation in the nicotinamide nucleotide transhydrogenase (Nnt) gene eliminating exons 7-11, resulting in expression of a truncated form of Nnt, an enzyme that pumps protons across the inner mitochondrial membrane. It has been proposed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, High-Fat
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mitochondrial Proteins

Share to Mutation

Share to Obesity

Share to Phenotype

Share to Weight Gain

Source

Identifiers

PMID: 32629517
DOI: 10.1055/a-1199-2257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice.PMID 32629517Read ↗

Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene.Semantic proximity Read ↗

The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose tolerance.Semantic proximity Read ↗

Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains.Semantic proximity Read ↗

Loss of Nnt Increases Expression of Oxidative Phosphorylation Complexes in C57BL/6J Hearts.Semantic proximity Read ↗

Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies.Semantic proximity Read ↗

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes.Semantic proximity Read ↗

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.Semantic proximity Read ↗

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.Semantic proximity Read ↗

Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains.Semantic proximity Read ↗

Genetic differences among C57BL/6 substrains.Semantic proximity Read ↗

C57BL/6JRj mice are protected against diet induced obesity (DIO).Semantic proximity Read ↗

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.