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Article

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.

PloS one - 22 Feb 2010

Gonzalvez François, Pariselli Fabrizio, Jalmar Olivier, Dupaigne Pauline, Sureau Franck, Dellinger Marc, Hendrickson Eric A, Bernard Sophie, Petit Patrice X

Abstract excerpt

BACKGROUND: The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by caspase-8 into its active form, tBid (truncated Bid), which then translocates to the mitochondria to trigger cytochrome c release an...

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Identifiers

PMID: 20179769
DOI: 10.1371/journal.pone.0009342
PMCID: PMC2825271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20179769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.PMID 20179769Read ↗

The interaction between tBid and cardiolipin or monolysocardiolipin.Semantic proximity Read ↗

tBid undergoes multiple conformational changes at the membrane required for Bax activation.Semantic proximity Read ↗

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Semantic proximity Read ↗

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation.Semantic proximity Read ↗

Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.Semantic proximity Read ↗

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and DeathSemantic proximity Read ↗

Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.Semantic proximity Read ↗

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Bid Protein: A Participant in the Apoptotic Network with Roles in Viral InfectionsSemantic proximity Read ↗

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.Semantic proximity Read ↗

Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.Semantic proximity Read ↗

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