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Article

Heterodimerization of BAK and MCL-1 activated by detergent micelles.

The Journal of biological chemistry - 24 Dec 2010

Liu Qian, Gehring Kalle

Abstract excerpt

BAK is a key protein mediating mitochondrial outer membrane permeabilization; however, its behavior in the membrane is poorly understood. Here, we characterize the conformational changes in BAK and MCL-1 using detergents to mimic the membrane environment and study their interaction by in vitro pulldown experiments, size exclusion chromatography, titration calorimetry, and NMR spectroscopy. The nonionic detergent...

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Identifiers

PMID: 21036904
DOI: 10.1074/jbc.M110.144857
PMCID: PMC3003418

Genes

BID

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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