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Article

Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.

PloS one - 1 Jan 2013

Golla Upendarrao, Singh Vikash, Azad Gajendra Kumar, Singh Prabhat, Verma Naveen, Mandal Papita, Chauhan Sakshi, Tomar Raghuvir S

Abstract excerpt

Gene expression is a multi-step process which requires recruitment of several factors to promoters. One of the factors, Sen1p is an RNA/DNA helicase implicated in transcriptional termination and RNA processing in yeast. In the present study, we have identified a novel function of Sen1p that regulates the expression of ribonucleotide reductase RNR1 gene, which is essential for maintaining genomic integrity. Cells...

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Identifiers

PMID: 23741394
DOI: 10.1371/journal.pone.0064798
PMCID: PMC3669351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.PMID 23741394Read ↗

Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing.Semantic proximity Read ↗

Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1.Semantic proximity Read ↗

The putative nucleic acid helicase Sen1p is required for formation and stability of termini and for maximal rates of synthesis and levels of accumulation of small nucleolar RNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sen1p performs two genetically separable functions in transcription and processing of U5 small nuclear RNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.Semantic proximity Read ↗

Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Inactivation of the yeast Sen1 protein affects the localization of nucleolar proteins.Semantic proximity Read ↗

SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae.Semantic proximity Read ↗

An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination.Semantic proximity Read ↗

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.Semantic proximity Read ↗

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