Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association Tests for Rare Variants.

Annual review of genomics and human genetics - 31 Aug 2016

Nicolae Dan L

Abstract excerpt

Over the past few years, interest in the identification of rare variants that influence human phenotype has led to the development of many statistical methods for testing for association between sets of rare variants and binary or quantitative traits. Here, I review some of the most important ideas that underlie these methods and the most relevant issues when choosing a method for analysis. In addition to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Genetic Variation
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Quantitative Trait Loci

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 27147090
DOI: 10.1146/annurev-genom-083115-022609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association Tests for Rare Variants.PMID 27147090Read ↗

Statistical analysis strategies for association studies involving rare variants.Semantic proximity Read ↗

Rare-variant association analysis: study designs and statistical tests.Semantic proximity Read ↗

A general framework for detecting disease associations with rare variants in sequencing studies.Semantic proximity Read ↗

Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits.Semantic proximity Read ↗

Detecting rare variants.Semantic proximity Read ↗

Robust and powerful tests for rare variants using Fisher's method to combine evidence of association from two or more complementary tests.Semantic proximity Read ↗

Association methods in human genetics.Semantic proximity Read ↗

Calculating the statistical significance of rare variants causal for Mendelian and complex disordersSemantic proximity Read ↗

Discovery of rare variants for complex phenotypes.Semantic proximity Read ↗

Identifying rare variants associated with complex traits via sequencing.Semantic proximity Read ↗

Rare variant association analysis methods for complex traits.Semantic proximity Read ↗

Methods for rare-variant association analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.