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Article

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele.

BMJ case reports - 9 Nov 2012

Tanna Anisha, Salama Alan D, Brookes Paul, Pusey Charles D

Abstract excerpt

The aetiology of granulomatosis with polyangiitis (GPA) remains unclear. There is likely a complex interplay between environmental triggers and genetic predisposition. Early diagnosis and treatment improve outcome in this condition with an untreated reported mortality of 90%. There are a few cases of familial GPA in the literature, but we report here the interesting and rare scenario of three members of the same...

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Identifiers

PMID: 23144337
DOI: 10.1136/bcr.01.2012.5502
PMCID: PMC4545082

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