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Article

Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.

International journal of cardiology - 9 Oct 2013

Smith Keith J, Chadburn Andrew J, Adomaviciene Aiste, Minoretti Piercarlo, Vignali Luigi, Emanuele Enzo, Tammaro Paolo

Abstract excerpt

BACKGROUND: Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we explore the pathophysiological mechanism of a rare mutation (V734I) found in exon 17 of the ABCC9...

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Identifiers

PMID: 23739550
DOI: 10.1016/j.ijcard.2013.04.210

Genes

ABCC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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