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Article

A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults.

PloS one - 1 Jan 2026

Shawer Heba, Cheng Chew W, Hemmings Karen E, Aldawsari Abeer M, Revilla-González Gonzalo, Stocco Fabio, Shi Jian, Beech David J, Bailey Marc A

Abstract excerpt

BACKGROUND: Pathological remodelling of native vascular smooth muscle cells (VSMC) within the arterial wall is a key contributor to vascular disease. A driver of this remodelling is platelet-derived growth factor BB (PDGF-BB) and its signalling via activation of the store-operated calcium ion channel, ORAI1. Here, we investigated if there are associations of ORAI1 polymorphisms with human cardiovascular disease....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41686842
DOI: 10.1371/journal.pone.0337519
PMCID: PMC12904380

Genes

ORAI1

Variants

rs3741596

Provenance

PubMed metadata and Literature Corpus relationships.

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