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Article

Explant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking.

Molecular vision - 1 Jan 2013

Bandyopadhyay Mausumi, Kono Masahiro, Rohrer Bärbel

Abstract excerpt

PURPOSE: In the absence of 11-cis retinal (e.g., Rpe65⁻/⁻), the chromophore for all pigments, cone opsins are mislocalized in vivo. Using the systemic application of 11-cis retinal, appropriate protein localization can be promoted. Here, we asked whether explant cultures of Rpe65⁻/⁻ mouse retina are amenable to screening retinoids for their ability to promote opsin trafficking. METHODS: Retina-retinal pigment...

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Source

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Identifiers

PMID: 23734084
PMCID: PMC3669539

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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