Article
An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jun 2012
Insinna Christine, Daniele Lauren L, Davis Jason A, Larsen DeLaine D, Kuemmel Colleen, Wang Jinhua, Nikonov Sergei S, Knox Barry E, Pugh Edward N
Abstract excerpt
In absence of their natural ligand, 11-cis-retinal, cone opsin G-protein-coupled receptors fail to traffic normally, a condition associated with photoreceptor degeneration and blindness. We created a mouse with a point mutation (F81Y) in cone S-opsin. As expected, cones with this knock-in mutation respond to light with maximal sensitivity red-shifted from 360 to 420 nm, consistent with an altered interaction...
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