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Article

Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.

Investigative ophthalmology & visual science - 1 Mar 2008

Feathers Kecia L, Lyubarsky Arkady L, Khan Naheed W, Teofilo Karen, Swaroop Anand, Williams David S, Pugh Edward N, Thompson Debra A

Abstract excerpt

PURPOSE: To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supplementation evaluated. METHODS: Rpe65(-)(/)(-)/Nrl(-)(/)(-) mice were generated by breeding Rpe65(-)(/)(-) and...

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Identifiers

PMID: 18326740
DOI: 10.1167/iovs.07-1234
PMCID: PMC4505835

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ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.PMID 18326740Read ↗

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