Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.

Investigative ophthalmology & visual science - 1 Mar 2008

Feathers Kecia L, Lyubarsky Arkady L, Khan Naheed W, Teofilo Karen, Swaroop Anand, Williams David S, Pugh Edward N, Thompson Debra A

Abstract excerpt

PURPOSE: To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic-Leucine Zipper Transcription Factors
Share to cis-trans-Isomerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dark Adaptation

Share to Injections, Intraperitoneal

Share to Retinal Cone Photoreceptor Cells

Share to Retinaldehyde

Share to Retinoids

Share to Rod Opsins

Source

Open in PubMed Open full text

Identifiers

PMID: 18326740
DOI: 10.1167/iovs.07-1234
PMCID: PMC4505835

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18326740-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.PMID 18326740Read ↗

In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.Semantic proximity Read ↗

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.Semantic proximity Read ↗

RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models.Semantic proximity Read ↗

<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersionSemantic proximity Read ↗

Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-Only<i>Nrl</i><sup>−/−</sup>Mouse RetinaSemantic proximity Read ↗

Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damageSemantic proximity Read ↗

Explant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking.Semantic proximity Read ↗

R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinalSemantic proximity Read ↗

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degenerationSemantic proximity Read ↗

Evidence for RPE65‐independent vision in the cone‐dominated zebrafish retinaSemantic proximity Read ↗

Pathways and disease-causing alterations in visual chromophore production for vertebrate visionSemantic proximity Read ↗

Human cone photoreceptor dependence on RPE65 isomeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.