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Article

Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.

Journal of molecular biology - 5 Feb 2010

Krebs Mark P, Holden David C, Joshi Parth, Clark Charles L, Lee Andrew H, Kaushal Shalesh

Abstract excerpt

Variants of rhodopsin, a complex of 11-cis retinal and opsin, cause retinitis pigmentosa (RP), a degenerative disease of the retina. Trafficking defects due to rhodopsin misfolding have been proposed as the most likely basis of the disease, but other potentially overlapping mechanisms may also apply. Pharmacological therapies for RP must target the major disease mechanism and contend with overlap, if it occurs....

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Identifiers

PMID: 19913029
DOI: 10.1016/j.jmb.2009.11.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.PMID 19913029Read ↗

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