Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

doi:10.1038/3813

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Article

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

Nature genetics - 1 Dec 1998

Redmond T M, Yu S, Lee E, Bok D, Hamasaki D, Chen N, Goletz P, Ma J X, Crouch R K, Pfeifer K

Abstract excerpt

Mutation of RPE65 can cause severe blindness from birth or early childhood, and RPE65 protein is associated with retinal pigment epithelium (RPE) vitamin A metabolism. Here, we show that Rpe65-deficient mice exhibit changes in retinal physiology and biochemistry. Outer segment discs of rod photor...

Topics

Animals
Carrier Proteins
Esters
Eye Proteins
Mice
Mice, Knockout
Microscopy, Electron
Mutation
Phenotype
Proteins
Retina
Retinal Rod Photoreceptor Cells
Rhodopsin
Vision, Ocular
Vitamin A
cis-trans-Isomerases

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