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<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersion

2025-08-18

Abstract excerpt

The isomerohydrolase RPE65 is a critical element of the visual cycle, the series of enzymatic reactions by which the chromophore of the visual pigments is regenerated following light exposure. In humans, mutations in the rpe65 gene cause a severe form of blindness called Leber’s congenital amaurosis. Studies of RPE65 -/- mice have shown dramatic depletion of 11- cis-retinal in the retina, resulting in a slow re...

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Literature Corpus work
8e36127a-35b0-5070-87b5-8dbeb788ec2b
DOI
10.1101/2025.08.15.670600
Open publication

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<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersionDOI 10.1101/2025.08.15.670600
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