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Article

Pharmacogenetics of methotrexate

1 Oct 2004

Abstract excerpt

Methotrexate (MTX) has proven efficient in the treatment of a number of malignancies, as well as non-malignant disorders characterized by a rapid cellular growth. Yet some patients might develop resistance, while others could have toxic side effects. MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the genes controlling their activity or the levels of folate...

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PMID: 15469405
DOI: 10.1517/14622416.5.7.819

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