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Article

Extreme QTL mapping enables the identification of novel zinc toxicity response loci in Drosophila melanogaster.

Genetics - 12 Nov 2025

Hanson Katherine M, Long Anthony D, Macdonald Stuart J

Abstract excerpt

Heavy metals are a widespread environmental contaminant, and even low levels of some metals can disrupt cellular processes and result in DNA damage. However, the consequences of metal exposure are variable among individuals, with susceptibility to metal toxicity representing a complex trait influenced by genetic and non-genetic factors. To uncover toxicity response genes, and better understand responses to metal...

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PMID: 40839771
DOI: 10.1093/genetics/iyaf173
PMCID: PMC12606420

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