Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.

Molecular and cellular endocrinology - 25 Aug 2013

Sugiyama Yuka, Ikeshita Nobuko, Shibahara Hiromi, Yamamoto Daisuke, Kawagishi Mayuko, Iguchi Genzo, Iida Keiji, Takahashi Yutaka, Kaji Hidesuke, Chihara Kazuo, Okimura Yasuhiko

Abstract excerpt

PROP1 mutation causes combined pituitary hormone deficiency (CPHD). Several mutations are located in a transactivation domain (TAD) of Prop1, and the loss of TAD binding to cofactors is likely the cause of CPHD. PROP1 cofactors have not yet been identified. In the present study, we aimed to identify the PROP1-interacting proteins from the human brain cDNA library. Using a yeast two-hybrid assay, we cloned nine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Co-Repressor Proteins
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Hypopituitarism

Share to Pituitary Gland

Share to Protein Interaction Domains and Motifs

Share to Transcription Factor Pit-1

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 23732115
DOI: 10.1016/j.mce.2013.05.022

Genes

PROP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.PMID 23732115Read ↗

PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cellsSemantic proximity Read ↗

Differential conservation of transcriptional domains of mammalian Prophet of Pit-1 proteins revealed by structural studies of the bovine gene and comparative functional analysis of the protein.Semantic proximity Read ↗

Atbf1 is required for the Pit1 gene early activation.Semantic proximity Read ↗

"Hot Spot" in the PROP1 Gene Responsible for Combined Pituitary Hormone DeficiencySemantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.Semantic proximity Read ↗

Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency.Semantic proximity Read ↗

"Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.Semantic proximity Read ↗

GH transcription factors.Semantic proximity Read ↗

Transcription factors regulating pituitary development.Semantic proximity Read ↗

Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.