Article
Drosophila GAGA factor polyglutamine domains exhibit prion-like behavior.
BMC genomics - 3 Jun 2013
Tariq Muhammad, Wegrzyn Renee, Anwar Saima, Bukau Bernd, Paro Renato
Abstract excerpt
BACKGROUND: The Drosophila GAGA factor (GAF) participates in nucleosome remodeling to activate genes, acts as an antirepressor and is associated with heterochromatin, contributing to gene repression. GAF functions are intimately associated to chromatin-based epigenetic control, linking basic transcriptional regulation to heritable long-term maintenance of gene expression. These diverse functions require GAF to...
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