Article
The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion.
Nature cell biology - 1 Mar 2009
Patel Basant K, Gavin-Smyth Jackie, Liebman Susan W
Abstract excerpt
Although many proteins can misfold into a self-seeding amyloid-like conformation, only six are known to be infectious, that is prions. The prions [PSI(+)], [PIN(+)], [URE3], [SWI(+)] and [HET-s] cause distinct heritable physiological changes in fungi, whereas PrP(Sc) causes infectious encephalopathies in mammals. It is unknown whether 'protein-only' inheritance is limited to these exceptional cases or whether it...
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