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Article

Dissection and design of yeast prions.

PLoS biology - 1 Apr 2004

Osherovich Lev Z, Cox Brian S, Tuite Mick F, Weissman Jonathan S

Abstract excerpt

Many proteins can misfold into beta-sheet-rich, self-seeding polymers (amyloids). Prions are exceptional among such aggregates in that they are also infectious. In fungi, prions are not pathogenic but rather act as epigenetic regulators of cell physiology, providing a powerful model for studying the mechanism of prion replication. We used prion-forming domains from two budding yeast proteins (Sup35p and New1p) to...

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Identifiers

PMID: 15045026
DOI: 10.1371/journal.pbio.0020086
PMCID: PMC374241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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