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Article

The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.

The Journal of biological chemistry - 27 Apr 2001

Lo K W, Naisbitt S, Fan J S, Sheng M, Zhang M

Abstract excerpt

Cytoplasmic dynein is a large, multisubunit molecular motor that translocates cargoes toward the minus ends of microtubules. Proper functioning of the dynein motor requires precise assembly of its various subunits. Using purified recombinant proteins, we show that the highly conserved 8-kDa light chain (DLC8) binds to the intermediate chain of the dynein complex. The DLC8-binding region was mapped to a highly...

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Identifiers

PMID: 11148209
DOI: 10.1074/jbc.M010320200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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