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Article

Pirin is an iron-dependent redox regulator of NF-κB.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013

Liu Fange, Rehmani Imran, Esaki Shingo, Fu Rong, Chen Lirong, de Serrano Vesna, Liu Aimin

Abstract excerpt

Pirin is a nuclear nonheme Fe protein of unknown function present in all human tissues. Here we describe that pirin may act as a redox sensor for the nuclear factor κB (NF-κB) transcription factor, a critical mediator of intracellular signaling that has been linked to cellular responses to proinf...

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Identifiers

PMID: 23716661
DOI: 10.1073/pnas.1221743110
PMCID: PMC3683729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23716661-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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