Pirin does not bind to p65 or regulate NFκB-dependent gene expression but does modulate cellular quercetin levels

Abstract excerpt

Pirin is a non-heme iron binding protein with a variety of proposed functions including serving as a co-activator of p65 NFκB and quercetinase activity. We report here, failure to confirm pirin’s primary proposed mechanism, binding of Fe(III)-pirin and p65. Analytical size exclusion chromatography (SEC) and fluorescence polarization (FP) studies did not detect an interaction. We also found no effects of pirin on T...

Topics

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• Dioxygenases
• Mice, 129 Strain
• Models, Animal
• NF-kappa B p50 Subunit
• NFI Transcription Factors
• Proto-Oncogene Mas
• Spleen
• Transcription Factor AP-1

Identifiers and source

Literature Corpus work

8d6b9277-503e-5f47-b867-0c8eb442806a

DOI

10.1101/2024.12.03.626411