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Article

Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.

The Journal of biological chemistry - 20 Oct 2006

Robinson John A, Chatterjee-Kishore Moitreyee, Yaworsky Paul J, Cullen Diane M, Zhao Weiguang, Li Christine, Kharode Yogendra, Sauter Linda, Babij Philip, Brown Eugene L, Hill Andrew A, Akhter Mohammed P, Johnson Mark L, Recker Robert R, Komm Barry S, Bex Frederick J

Abstract excerpt

A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the high bone mass LRP5 G171V transgenic mice demonstrated increased expression of canonical Wnt pathway and Wnt/beta-catenin target genes compared with non-transgenic explant derived osteoblasts. Therefore, expression of Wnt/beta-catenin target genes were monitored after in vivo loading of the tibia of LRP5 G171V transgenic...

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Source

Identifiers

PMID: 16908522
DOI: 10.1074/jbc.M602308200

Genes

LRP5
SFRP1

Variants

Provenance

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