Article
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.
Lancet (London, England) - 16 Jun 2001
Hampe J, Cuthbert A, Croucher P J, Mirza M M, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson A J, Bridger S, van Deventer S, Forbes A, Nikolaus S, Lennard-Jones J E, Foelsch U R, Krawczak M, Lewis C, Schreiber S, Mathew C G
Abstract excerpt
Background Genetic predisposition to inflammatory bowel disease (IBD) has been shown by epidemiological and linkage studies. Genetic linkage of IBD to chromosome 16 has been previously observed and replicated in independent populations. The recently identified NOD2 gene is a good positional and functional candidate gene since it is located in the region of linkage on chromosome 16q12, and activates nuclear factor...
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