Article
ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas.
Cell death & disease - 23 Apr 2020
Huang Chuang, Yoon Changhwan, Zhou Xiao-Hong, Zhou Ying-Chun, Zhou Wen-Wen, Liu Hong, Yang Xin, Lu Jun, Lee Sei Young, Huang Kun
Abstract excerpt
Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44(+) and present with malignancy and radiotherapy resistance. As a key regulator of self-renewal, Nanog expression not only determines cell fate in pluripotent cells but also mediates tumorigenesis in cancer cells; thus, we examined the role of Nanog in CD44(+) HNSCC. Three HNSCC cell lines, tumor xenografts, and patient tumors...
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