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Article

Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers.

Oncotarget - 29 Nov 2016

Cheng Li-Hao, Hung Kai-Feng, Huang Tung-Fu, Hsieh Hsin-Pei, Wang Shu-Ying, Huang Chih-Yang, Lo Jeng-Fan

Abstract excerpt

S100A4 is a calcium-binding protein capable of promoting epithelial-mesenchymal transition. Previously, we have demonstrated that S100A4 is required to sustain the head and neck cancer-initiating cells (HN-CICs) subpopulation. In this study, to further investigate the molecular mechanism, we established the head and neck squamous cell carcinoma (HNSCC) cell lines stably expressing mutant S100A4 proteins with...

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Identifiers

PMID: 27793047
DOI: 10.18632/oncotarget.12935
PMCID: PMC5346689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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