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Article

The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2014

Kljajevic Vanja, Meyer Peter, Holzmann Carsten, Dyrba Martin, Kasper Elisabeth, Bokde Arun L W, Fellgiebel Andreas, Meindl Thomas, Hampel Harald, Teipel Stefan

Abstract excerpt

BACKGROUND: In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). METHODS: We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4...

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Source

Identifiers

PMID: 23706516
DOI: 10.1016/j.jalz.2013.02.008

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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