Article
Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.
BMC infectious diseases - 24 May 2013
Zimenkov Danila V, Antonova Olga V, Kuz'min Alexey V, Isaeva Yulia D, Krylova Ludmila Y, Popov Sergey A, Zasedatelev Alexander S, Mikhailovich Vladimir M, Gryadunov Dmitry A
Abstract excerpt
BACKGROUND: The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectrum of mutations to be identified or are not easily implemented in clinical laboratories. A...
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