Article
Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2013
Moure Raquel, Tudó Griselda, Medina Rebeca, Vicente Eva, Caldito José María, Codina Maria Gemma, Coll Pere, Español Montserrat, Gonzalez-Martin Julian, Rey-Jurado Emma, Salvadó Margarita, Tórtola Maria Teresa, Alcaide Fernando
Abstract excerpt
In cases of multidrug-resistant tuberculosis, it is crucial to rule out resistance to second-line antituberculous (anti-TB) agents. In the present study, a low-cost low-density DNA array including four genetic regions (rrs 530 loop, rrs 1400, rpsL and gyrA) was designed for the rapid detection of the most important mutations related to anti-TB injectable drugs (mainly streptomycin) and fluoroquinolone resistance...
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