Article
Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Volokhov Dmitriy V, Chizhikov Vladimir E, Denkin Steven, Zhang Ying
Abstract excerpt
The increasing emergence of drug-resistant Mycobacterium tuberculosis poses significant threat to the treatment of tuberculosis (TB). Conventional drug susceptibility testing is time-consuming and takes several weeks because of the slow growth rate of M. tuberculosis and the requirement for the drugs to show antimycobacterial activity. Resistance to TB drugs in M. tuberculosis is caused by mutations in the...
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