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Article

Caspase-1 is a novel target of p63 in tumor suppression

23 May 2013

Abstract excerpt

p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (transactivation domain (TA)p63 and amino terminal truncated protein(ΔN)p63); in addition alternative splicing at the 5'-end give rise to at least five C-terminal...

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PMID: 23703390
DOI: 10.1038/cddis.2013.175

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