Article
Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis.
International journal of molecular sciences - 8 Mar 2026
Zikopoulos Athanasios, Moustakli Efthalia, Katopodis Periklis, Paraschos Vasilis Sebastian, Potiris Anastasios, Anagnostaki Ismini, Vogiatzoglou Aikaterini Lydia, Zacharis Konstantinos, Karampitsakos Theodoros, Zikopoulos Konstantinos, Stavros Sofoklis
Abstract excerpt
Adipocytes produce the hormone leptin, a hormone that links energy availability to reproductive function by permitting activation of the hypothalamic-pituitary-gonadal (HPG) axis. Loss-of-function mutations in the long leptin receptor isoform (LEPRb) disrupt intracellular signaling pathways, including the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3), phosphoinositide 3-kinase...
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