Article
Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm.
American journal of physiology. Endocrinology and metabolism - 15 Jul 2013
Miura Shinji, Kai Yuko, Tadaishi Miki, Tokutake Yuka, Sakamoto Kimitoshi, Bruce Clinton R, Febbraio Mark A, Kita Kiyoshi, Chohnan Shigeru, Ezaki Osamu
Abstract excerpt
LKB1 phosphorylates members of the AMP-activated protein kinase (AMPK) family. LKB1 and AMPK in the skeletal muscle are believed to regulate not only fuel oxidation during exercise but also exercise capacity. LKB1 was also required to prevent diaphragm fatigue, which was shown to affect exercise performance. Using mice expressing dominant negative (DN) mutants of LKB1 and AMPK, specifically in the skeletal muscle...
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