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Article

Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α and BNIP3-mediated mitophagy.

The Journal of physiology - 1 Dec 2018

Von Schulze Alex, McCoin Colin S, Onyekere Chiemela, Allen Julie, Geiger Paige, Dorn Gerald W, Morris E Matthew, Thyfault John P

Abstract excerpt

KEY POINTS: Hepatic mitochondrial adaptations to physical activity may be regulated by mitochondrial biogenesis (PGC1α) and mitophagy (BNIP3). Additionally, these adaptations may be sex-dependent. Chronic increase in physical activity lowers basal mitochondrial respiratory capacity in mice. Female mice have higher hepatic electron transport system protein content, elevated respiratory capacity, lowered mitophagic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30062822
DOI: 10.1113/JP276539
PMCID: PMC6292817

Genes

BNIP3
BCL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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