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Article

Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas

21 May 2013

Abstract excerpt

PURPOSE: miR-452 is reported to be required for neural crest stem cell differentiation during neural crest development. However, the biologic role of miR-452 in gliomas remains unclear. The aim of the present study was to evaluate the effect of miR-452 on the stem-like properties and tumorigenesis of glioma cells. EXPERIMENTAL DESIGN: The expression of miR-452 was examined in glioma cells and glioma tissues using...

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PMID: 23695168
DOI: 10.1158/1078-0432.ccr-12-3794

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