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Article

Long non-coding RNA GAS5, by up-regulating PRC2 and targeting the promoter methylation of miR-424, suppresses multiple malignant phenotypes of glioma.

Journal of neuro-oncology - 1 Jul 2020

Jin Chen, Zhao Jie, Zhang Zhi-Ping, Wu Ming, Li Jian, Xiao Ge-Lei, Liu Bo, Liao Yu-Xiang, Liu Jing-Ping

Abstract excerpt

PURPOSE: Malignant gliomas remain significant challenges in clinic and pose dismal prognosis on patients. In this study, we focused on growth arrest-specific 5 (GAS5), a tumor suppressive long non-coding RNA in glioma, explored its crosstalk with miR-424, and examined their biological functions in glioma. METHODS: Expressions of GAS5 and miR-424 were measured using qRT-PCR. The regulation of GAS5 on miR-424...

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Identifiers

PMID: 32472311
DOI: 10.1007/s11060-020-03544-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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