Article
Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival.
Scientific reports - 12 Feb 2018
Sana Jiri, Busek Petr, Fadrus Pavel, Besse Andrej, Radova Lenka, Vecera Marek, Reguli Stefan, Stollinova Sromova Lucie, Hilser Marek, Lipina Radim, Lakomy Radek, Kren Leos, Smrcka Martin, Sedo Aleksi, Slaby Ondrej
Abstract excerpt
Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression at the post-transcriptional level, which are known to be important regulators of the stem-like features. Moreover, miRNAs have been previously proved to be promising diagnostic...
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