Subclinical fields of BRAF V600E-mutant melanocytes populate human skin and are enriched around melanoma and naevi.

doi:10.1093/bjd/ljaf412

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Article

Subclinical fields of BRAF V600E-mutant melanocytes populate human skin and are enriched around melanoma and naevi.

The British journal of dermatology - 27 Jan 2026

Lee Katie J, Kao Yung-Ching, Jiang Amanda, Prokofyeva Anastasia, Tom Lisa N, Jagirdar Kasturee, Smit Darren J, Oey Harald M, Tan Jean-Marie, Ainger Stephen A, Huang Nancy, Tuong Zewen Kelvin, Andersen Stacey, Senabouth Anne, Powell Joseph E, Lambie Duncan, Schaider Helmut, Soyer H Peter, Sturm Richard A, Welm Alana L, Grossman Douglas, Judson-Torres Robert L, Stark Mitchell S

Abstract excerpt

BACKGROUND: The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g. melanocytic naevi), but approximately two-thirds of melanomas arise from clinically healthy skin with no detectable precursor lesion. The BRAF V600E mutation drives melanoma and naevus formation, but eruptive naevi syndromes and the disproportionate role early-life ultraviolet exposure plays in melanoma risk suggest...

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Identifiers

PMID: 41148046
DOI: 10.1093/bjd/ljaf412
PMCID: PMC13346663

Genes

BRAF

Variants

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