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Article

Polyclonality of BRAF mutations in acquired melanocytic nevi.

Journal of the National Cancer Institute - 21 Oct 2009

Lin Jingrong, Takata Minoru, Murata Hiroshi, Goto Yasufumi, Kido Kenji, Ferrone Soldano, Saida Toshiaki

Abstract excerpt

Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation. BRAF mutation is considered to be a crucial step in the initiation of melanocyte transformation. However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 19752400
DOI: 10.1093/jnci/djp309
PMCID: PMC2765260

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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