Article
Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression.
British journal of cancer - 1 Feb 2011
Lin J, Goto Y, Murata H, Sakaizawa K, Uchiyama A, Saida T, Takata M
Abstract excerpt
BACKGROUND: Oncogenic BRAF mutation had been considered to be a founder event in the formation of melanocytic tumours; however, we recently argued against this notion by showing marked polyclonality of BRAF mutations in acquired melanocytic nevi (Lin et al, J Natl Cancer Inst., 2009; 101:1423-7). Here, we tested whether similar heterogeneity of BRAF mutations exists in primary melanomas. METHODS: We isolated and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.