Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cocaine represses protein phosphatase-1Cβ through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain.

Neuropharmacology - 1 Oct 2013

Pol Bodetto Sarah, Carouge Delphine, Fonteneau Mathieu, Dietrich Jean-Bernard, Zwiller Jean, Anglard Patrick

Abstract excerpt

Repeated cocaine exposure induces epigenetic factors such as DNA methyl-binding proteins, indicating that resulting changes in gene expression are mediated by alterations in brain DNA methylation. While the activity of protein phosphatase type-1 (PP1) is involved in cocaine effects and in brain plasticity, the expression of the PP1Cβ catalytic subunit gene was identified here as modulated by cocaine. Its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caudate Nucleus
Share to Cocaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methylation

Share to DNA Methyltransferase 3A

Share to Protein Phosphatase 1

Share to Protein Subunits

Share to Putamen

Source

Identifiers

PMID: 23688924
DOI: 10.1016/j.neuropharm.2013.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cocaine represses protein phosphatase-1Cβ through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain.PMID 23688924Read ↗

DNA Methylation Dynamics and Cocaine in the Brain: Progress and ProspectsSemantic proximity Read ↗

Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1+/- miceSemantic proximity Read ↗

Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in miceSemantic proximity Read ↗

Cytoplasmic FMR1-interacting protein 2 regulates cocaine reward by modulating synaptic plasticity in the nucleus accumbensSemantic proximity Read ↗

The mutated cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)-interacting protein 2 (CYFIP2 S968F) regulates cocaine-induced reward behaviour and plasticity in the nucleus accumbens.Semantic proximity Read ↗

Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1+/- miceSemantic proximity Read ↗

Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerveSemantic proximity Read ↗

Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.Semantic proximity Read ↗

MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.Semantic proximity Read ↗

Association of the PLCB1 gene with drug dependence.Semantic proximity Read ↗

Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes.Semantic proximity Read ↗

Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.